Rivus raises $132 million to advance scientific growth of weight problems remedy

Rivus Prescribed drugs has raised $132 million in Collection B funding to clinically advance its lead candidate, HU6, for the remedy of weight problems and cardiometabolic issues.

RA Capital Administration led the funding spherical, wherein Bain Capital Life Sciences and BB Biotech additionally participated.

The corporate’s present buyers, together with Longitude Capital, Medicxi and RxCapital, additionally participated within the spherical.

A managed metabolic accelerator (CMA), HU6 can deal with cardiometabolic ailments by addressing weight problems, which is a key driver of the ailments.

The corporate’s CMAs can scale back fats all through the physique by uncoupling mitochondria, a pure course of that causes power regulation.

Rivus beforehand reported findings from an eight-week part IIa metabolic examine in overweight sufferers.

The information set up proof of idea that CMAs can doubtlessly deal with weight problems and numerous cardiometabolic ailments, together with coronary heart failure with preserved ejection fraction (HFpEF), nonalcoholic fatty liver illness/nonalcoholic steatohepatitis, and kind 2 diabetes.

Within the examine, HU6 remedy additionally resulted in vital declines in liver, visceral, and complete physique fats whereas preserving skeletal muscle mass.

A part IIa trial involving overweight sufferers with HFpEF was lately initiated, whereas a part IIb trial in weight problems involving a subset of overweight sufferers with sort 2 diabetes is deliberate to start subsequent yr.

Rivus Prescribed drugs President and CEO Alan Cunningham stated, “We now have an distinctive group of buyers who share our imaginative and prescient to carry a brand new class of remedies to sufferers with weight problems and cardiometabolic illness.

“Following the encouraging information from our Part IIa scientific trial in overweight sufferers, this funding permits us to advance the event of HU6 and a sequence of managed metabolic accelerators to deal with a variety of cardiometabolic situations.”

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