Nanotechnology Now – Press Launch: Quantum-Si’s next-generation single-molecule protein sequencing know-how printed in Science, signaling new period of life science and biomedical analysis: Semiconductor chip and Time Area Sequencing™ know-how will advance drug discovery and diagnostics, enabling individuals to li

House > Press > Quantum-Si’s next-generation single-molecule protein sequencing know-how printed in Science, signaling new period of life science and biomedical analysis: Semiconductor chip and Time Area Sequencing™ know-how will advance drug discovery and diagnostics, enabling individuals to li

Summary:
Quantum-Si Included (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Firm”), a life sciences firm commercializing the primary next-generation single-molecule protein sequencing platform, in the present day introduced that Science, the peer-reviewed tutorial journal of the American Affiliation for the Development of Science, printed new analysis showcasing how single-molecule protein sequencing through semiconductor chip and Time Area Sequencing™ applied sciences will remodel life science and biomedical analysis. This primary-of-its-kind sequencing course of, which supplies an unparalleled understanding of proteins, will advance drug discovery and diagnostics and produce transformative well being and illness insights to the world.

Quantum-Si’s next-generation single-molecule protein sequencing know-how printed in Science, signaling new period of life science and biomedical analysis: Semiconductor chip and Time Area Sequencing™ know-how will advance drug discovery and diagnostics, enabling individuals to li

Guilford, CT | Posted on October 14th, 2022

Based by world-renowned scientist, entrepreneur, and Nationwide Medal of Expertise and Innovation recipient Dr. Jonathan Rothberg, Quantum-Si developed its next-generation single-molecule protein sequencing know-how to create higher, extra complete methods to analysis proteins – and to affect the prognosis of contemporary illnesses.

“I’m proud and excited to share our first next-generation single-molecule protein sequencing know-how with the world,” stated Dr. Rothberg, senior writer of the paper. “Simply because the work I did with my first genomics collaborators on DNA sequencing led to a Nobel Prize for Svante Pääbo, I absolutely anticipate the early adopters of Quantum-Si’s know-how to make discoveries simply as profound and impactful.”

As described in Science’s publication of “Actual-time dynamic single-molecule protein sequencing on an built-in semiconductor gadget,” Quantum-Si’s semiconductor chip incorporates hundreds of thousands of wells, permitting for the cataloging of many proteins in parallel and the understanding of how these proteins are modified on the single-molecule stage. The corporate’s next-generation sequencing system detects and cleaves amino acids utilizing proteins and enzymes derived from naturally occurring pathways that perform the same course of in cells. This method eliminates roadblocks of complicated chemistry and enormous, costly tools going through different applied sciences, whereas offering the sensitivity, scalability, and accessibility wanted to speed up biomedical analysis.

“The idea of a small benchtop instrument finishing up massively-parallel sequencing of particular person protein molecules was beforehand unimaginable,” stated Brian D. Reed, Ph.D, co-author of the examine and Head of Analysis at Quantum-Si. “Researchers have used oblique strategies to know proteins and have been ready for instruments that may be transformative for proteomics in the identical approach that DNA sequencing has been for genomics. Our platform’s capability to map protein modifications, which have been troublesome to detect with different applied sciences, will drastically advance our understanding of the perform and regulation of proteins in well being and illness.”

Further info on Quantum-Si’s single-molecule protein sequencing course of, as outlined within the Science examine, embrace:

A dynamic method during which single peptides are probed in real-time by a mix of dye-labeled N-terminal amino acid recognizers and concurrently cleaved by aminopeptidases;
Annotation of amino acids and identification of the peptide sequence by measuring fluorescence depth, lifetime, and binding kinetics on an built-in semiconductor chip;
Recognizers determine a number of amino acids in an information-rich method that permits discrimination of single amino acid substitutions and post-translational modifications (PTMs), permitting for a extra detailed image of particular person proteins and their variations for future illness identification and prevention.
The peer-reviewed article titled “Actual-time dynamic single-molecule protein sequencing on an built-in semiconductor” seems within the October 14, 2022 concern of Science and is obtainable on-line and in print. Extra info, together with a duplicate of the paper, will be discovered on-line on the Science press bundle at .

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To be taught extra about Quantum-Si and the corporate’s proteomics know-how, go to www.quantum-si.com.

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About Quantum-Si
Quantum-Si is targeted on revolutionizing the rising discipline of proteomics. The Firm’s suite of applied sciences is powered by a first-of-its-kind semiconductor chip designed to allow single-molecule next-generation protein sequencing and digitize proteomic analysis as a way to advance drug discovery and diagnostics past what has been doable with DNA sequencing. Study extra at www.quantum-si.com.

Ahead Wanting Statements

This press launch contains “forward-looking statements” throughout the which means of the “protected harbor” provisions of america Personal Securities Litigation Reform Act of 1995. The precise outcomes of the Firm might differ from its expectations, estimates, and projections and, consequently, you shouldn’t depend on these forward-looking statements as predictions of future occasions. Phrases akin to “anticipate,” “estimate,” “undertaking,” “finances,” “forecast,” “anticipate,” “intend,” “plan,” “might,” “will,” “may,” “ought to,” “believes,” “predicts,” “potential,” “proceed,” and comparable expressions (or the unfavorable variations of such phrases or expressions) are supposed to determine such forward-looking statements. These forward-looking statements embrace, with out limitation, the Firm’s expectations with respect to future efficiency and growth and commercialization of services and products. These forward-looking statements contain vital dangers and uncertainties that might trigger the precise outcomes to vary materially from these mentioned within the forward-looking statements. Most of those components are exterior the Firm’s management and are troublesome to foretell. Elements that will trigger such variations embrace, however should not restricted to: the influence of COVID-19 on the Firm’s enterprise; the lack to take care of the itemizing of the Firm’s Class A standard inventory on The Nasdaq Inventory Market; the flexibility to acknowledge the anticipated advantages of the enterprise mixture, which can be affected by, amongst different issues, competitors and the flexibility of the Firm to develop and handle development profitably and retain its key staff; our ongoing management transition; modifications in relevant legal guidelines or laws; the flexibility of the Firm to boost financing sooner or later; the success, value and timing of the Firm’s product growth and commercialization actions; the potential attributes and advantages of the Firm’s services and products; the Firm’s capability to acquire and preserve regulatory approval for its merchandise, and any associated restrictions and limitations of any authorized product; the Firm’s capability to determine, in-license or purchase further know-how; the Firm’s capability to take care of its current lease, license, manufacture and provide agreements; the Firm’s capability to compete with different firms presently advertising and marketing or engaged within the growth or commercialization of services and products that the Firm is growing; the dimensions and development potential of the markets for the Firm’s future services and products, and its capability to serve these markets, both alone or in partnership with others; the pricing of the Firm’s services and products following anticipated business launch; the Firm’s estimates relating to future bills, future income, capital necessities and wishes for extra financing; the Firm’s monetary efficiency; and different dangers and uncertainties described below “Danger Elements” within the Firm’s Annual Report for the fiscal 12 months ended December 31, 2021, and within the Firm’s different filings with the SEC. The Firm cautions that the foregoing listing of things shouldn’t be unique. The Firm cautions readers to not place undue reliance upon any forward-looking statements, which communicate solely as of the date made. The Firm doesn’t undertake or settle for any obligation or enterprise to launch publicly any updates or revisions to any forward-looking statements to replicate any change in its expectations or any change in occasions, circumstances, or circumstances on which any such assertion relies.

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For extra info, please click on right here

Contacts:
Shawna Marino
Quantum-Si

Cell: (978) 273-8478
Skilled Contact

Brian Reed, Head of Analysis
Quantum-Si

Copyright © Quantum-Si

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